Read Full Report Abstract Osteoarthritis (OA) affects over 40 million people annually. We evaluated interleukin-1 receptor antagonist (IL-1ra) gene transfer in an equine model based on IL-1ra protein therapy which inhibits inflammation through blocking IL-1. Using the self-complementary adeno-associated virus (scAAV)IL-1ra equine gene as a starting construct, we optimized the transgene cassette by analyzing [...]
The painful inflammation and debilitating joint damage characteristic of rheumatoid arthritis may be reduced or prevented with a new approach using small-molecule enzyme mimetics, according to research published in the journal Arthritis & Rheumatism. The preclinical study conducted by researchers at MetaPhore Pharmaceuticals, Inc.® and the University of Messina, Italy showed that a superoxide dismutase [...]
